BIOGEOGRAPHY OF SPECIATION OF TWO SISTER SPECIES OF NEOTROPICAL AMAZONA (AVES, PSITTACIFORMES) BASED ON MITOCHONDRIAL SEQUENCE DATA.

Biogeography of speciation of two sister species of neotropical amazona (Aves, Psittaciformes) based on mitochondrial sequence data.

Coalescent theory provides powerful models for population genetic inference and is now increasingly important in estimates of divergence times and speciation research.We use molecular data and methods based on coalescent theory to investigate whether genetic evidence supports the hypothesis of A.pretrei and A.tucumana as separate species and whethe

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Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins.Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 and PC7.The binding pockets of all seven proprotein convertases are evolutionarily conserved and h

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